|Application ||IHC-P, E|
|Calculated MW||521958 Da|
|Antigen Region||4626-4655 aa|
|Other Names||Low-density lipoprotein receptor-related protein 2, LRP-2, Glycoprotein 330, gp330, Megalin, LRP2|
|Target/Specificity||This LRP2 (Megalin) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4626-4655 amino acids from the C-terminal region of human LRP2 (Megalin).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LRP2 (Megalin) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane, coated pit|
|Tissue Location||Absorptive epithelia, including renal proximal tubules|
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Provided below are standard protocols that you may find useful for product applications.
Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).
Christensen, E.I., et al., Nat. Rev. Mol. Cell Biol. 3(4):256-266 (2002).
Hjalm, G., et al., Eur. J. Biochem. 239(1):132-137 (1996).
Farquhar, M.G., et al., J. Am. Soc. Nephrol. 6(1):35-47 (1995).
Kounnas, M.Z., et al., J. Biol. Chem. 270(22):13070-13075 (1995).
Korenberg, J.R., et al., Genomics 22(1):88-93 (1994).
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