|Application ||WB, IHC-P, IF, E|
|Calculated MW||29677 Da|
|Antigen Region||117-146 aa|
|Other Names||Matrilysin, Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase, MMP7, MPSL1, PUMP1|
|Target/Specificity||This MMP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the Central region of human MMP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP7 degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Filippov, S., et al., J. Exp. Med. 198(6):925-935 (2003). Rivat, C., et al., FASEB J. 17(12):1721-1723 (2003). Fu, X., et al., J. Biol. Chem. 278(31):28403-28409 (2003). McGuire, J.K., et al., Am. J. Pathol. 162(6):1831-1843 (2003). Sumi, T., et al., Oncol. Rep. 10(2):345-349 (2003).
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