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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MMP8 Antibody (Center)   

MMP8 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MMP8 Antibody (Center) AP6213a
    Western blot analysis of anti-MMP8 Pab (Cat. #AP6213a) in mouse liver tissue lysate (35ug/lane). MMP8 (arrow) was detected using the purified Pab
  • IHC-P - MMP8 Antibody (Center) AP6213a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22894
Other Accession NP_002415
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53412 Da
Antigen Region 286-315 aa
Additional Information
Gene ID 4317
Other Names Neutrophil collagenase, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, MMP8, CLG1
Target/Specificity This MMP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human MMP8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP8
Synonyms CLG1
Function Can degrade fibrillar type I, II, and III collagens.
Cellular Location Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules
Tissue Location Neutrophils.
Research Areas
Citations (0)

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP8 is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.


Van den Steen, P.E., et al., Biochem. Biophys. Res. Commun. 310(3):889-896 (2003). Giambernardi, T.A., et al., Matrix Biol. 20(8):577-587 (2001). Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999). Massova, I., et al., FASEB J. 12(12):1075-1095 (1998). Pendas, A.M., et al., Genomics 37(2):266-268 (1996).

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$ 295.00
$ 99.00
Cat# AP6213a
(40 western blots)
Availability: In Stock
Bulk Size
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