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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MVP Antibody (C-term)   

MVP Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MVP Antibody (C-term) AP6216A
    The anti-MVP C-term Antibody (Cat.#AP6216a) is used in Western blot to detect MVP in A375 lysate.
  • WB - MVP Antibody (C-term) AP6216A
    Western blot analysis of MVP (arrow) using rabbit polyclonal MVP C-term Antibody (Cat.#AP6216a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MVP gene (Lane 2) (Origene Technologies).
  • IHC-P - MVP Antibody (C-term) AP6216A
    Formalin-fixed and paraffin-embedded human lung carcinoma with MVP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - MVP Antibody (C-term) AP6216A
    Flow cytometric analysis of NCI-H292 cells using MVP Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14764
Other Accession NP_005106
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 99327 Da
Antigen Region 863-893 aa
Additional Information
Gene ID 9961
Other Names Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
Target/Specificity This MVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 863-893 amino acids from the C-terminal region of human MVP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMVP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVP
Synonyms LRP
Function Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Cellular Location Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment
Tissue Location Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells
Research Areas
Citations (0)

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MVP, the major vault protein, is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance.


Aronica, E., et al., Epilepsia 44(9):1166-1175 (2003).
Klunder, J.W., et al., Hum. Pathol. 34(2):150-155 (2003).
Burger, H., et al., Clin. Cancer Res. 9(2):827-836 (2003).
Yu, Z., et al., J. Biol. Chem. 277(43):40247-40252 (2002).
van den Heuvel-Eibrink, M.M., et al., Leukemia 16(5):833-839 (2002).

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Cat# AP6216A
(40 western blots)
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