|Application ||WB, IHC-P, E|
|Other Accession||Q66HA2, Q9Z125, NP_443086|
|Calculated MW||57005 Da|
|Antigen Region||491-519 aa|
|Other Names||Cyclic AMP-responsive element-binding protein 3-like protein 1, cAMP-responsive element-binding protein 3-like protein 1, Old astrocyte specifically-induced substance, OASIS, Processed cyclic AMP-responsive element-binding protein 3-like protein 1, CREB3L1, OASIS|
|Target/Specificity||This OASIS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-519 amino acids from the C-terminal region of human OASIS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OASIS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.|
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Provided below are standard protocols that you may find useful for product applications.
OASIS is a putative CREB/ATF family transcription factor with a putative C-terminal hydrophobic transmembrane domain. It can activate transcription through box-B elements but not through CRE of somatostatin. Shortening of the OASIS transmembrane domain results in a significant increase in transcriptional activity and changes its subcellular localization from the endoplasmic reticulum to the nucleus.
Omori, Y., et al., Biochem. Biophys. Res. Commun. 293(1):470-477 (2002).
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