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SMYD5 (RAI15) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6GMV2 |
| Other Accession | Q3TYX3, NP_006053 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47341 Da |
| Antigen Region | 341-371 aa |
| Gene ID | 10322 |
|---|---|
| Other Names | SET and MYND domain-containing protein 5, 211-, Protein NN8-4AG, Retinoic acid-induced protein 15, SMYD5, RAI15 |
| Target/Specificity | This SMYD5 (RAI15) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-371 amino acids from the C-terminal region of human SMYD5 (RAI15). |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SMYD5 (RAI15) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMYD5 |
|---|---|
| Synonyms | RAI15 |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self- renewal and differentiation (By similarity). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of the protein for this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development.
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