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RAI17 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6236a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 1
- Reviews
- Protocols
- Backgrounds
RAI17 Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q9ULJ6 |
| Other Accession | Q6P1E1 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 115483 Da |
RAI17 Antibody (C-term) - Additional info | |
| Gene ID 57178 | |
| Other Names ZMIZ1; KIAA1224; RAI17; ZIMP10; Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; Retinoic acid-induced protein 17 | |
| Target/Specificity This RAI17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 596~626 amino acids from the C-terminal region of human RAI17. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RAI17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RAI17 Antibody (C-term) - Protein Information | |
| Name ZMIZ1 | |
| Synonyms KIAA1224, RAI17, ZIMP10 | |
| Function Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation | |
| Cellular Location Nucleus speckle. Cytoplasm. | |
| Tissue Location Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes | |
RAI17 Antibody (C-term) - Related products
AP6236a: RAI17 Antibody (C-term)
RAI17 Antibody (C-term) - Application data
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The anti-Rai17 C-term Antibody (Cat.#AP6236a) is used in Western blot to detect Rai17 in Placenta lysate.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
RAI17 Antibody (C-term) - Research Areas
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BACKGROUND
Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
