|Application ||WB, IHC-P, E|
|Calculated MW||94770 Da|
|Antigen Region||826-855 aa|
|Other Names||Suppressor of tumorigenicity 14 protein, Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein, ST14, PRSS14, SNC19, TADG15|
|Target/Specificity||This ST14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-855 amino acids from the C-terminal region of human ST14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ST14 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PRSS14, SNC19, TADG15|
|Function||Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Santin, A.D., et al., Cancer 98(9):1898-1904 (2003).
Oberst, M.D., et al., J. Biol. Chem. 278(29):26773-26779 (2003).
Ihara, S., et al., J. Biol. Chem. 277(19):16960-16967 (2002).
Benaud, C.M., et al., Clin. Exp. Metastasis 19(7):639-649 (2002).
Benaud, C., et al., J. Biol. Chem. 277(12):10539-10546 (2002).
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