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HES1 Antibody (N-term T24)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HES1 Antibody (N-term T24) AP6276a
    Western blot analysis of anti-HES1 Antibody (N-term T24) (RB13980) in HL60 cell line lysates (35ug/lane). HES1 (arrow) was detected using the purified Pab.
  • IF - HES1 Antibody (N-term T24) AP6276a
    Confocal immunofluorescent analysis of HES1 Antibody (N-term T24)(Cat#AP6276a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
  • FC - HES1 Antibody (N-term T24) AP6276a
    HES1 Antibody (N-term T24) (Cat. #AP6276a) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14469
Other Accession Q04666, P35428, Q3ZBG4, Q8AVU4, Q6IRB2
Reactivity Human
Predicted Mouse, Rat, Xenopus, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29541 Da
Antigen Region 9-38 aa
Additional Information
Gene ID 3280
Other Names Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY
Target/Specificity This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human HES1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHES1 Antibody (N-term T24) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HES1
Synonyms BHLHB39, HL, HRY
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Cellular Location Nucleus.
Research Areas
Citations (0)

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HES1 belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.


Liu,J., Int. J. Gynecol. Cancer 17 (6), 1293-1299 (2007)
Karlsson,C., J. Orthop. Res. 25 (2), 152-163 (2007)

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Cat# AP6276a
(40 western blots)
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