|Application ||WB, IF, FC, E|
|Other Accession||Q04666, P35428, Q3ZBG4, Q8AVU4, Q6IRB2|
|Predicted||Xenopus, Bovine, Mouse, Rat|
|Calculated MW||29541 Da|
|Antigen Region||9-38 aa|
|Other Names||Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY|
|Target/Specificity||This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human HES1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HES1 Antibody (N-term T24) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHB39, HL, HRY|
|Function||Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.|
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Provided below are standard protocols that you may find useful for product applications.
HES1 belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Liu,J., Int. J. Gynecol. Cancer 17 (6), 1293-1299 (2007)
Karlsson,C., J. Orthop. Res. 25 (2), 152-163 (2007)
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