|Application ||WB, E|
|Other Accession||P41969, A4GTP4|
|Calculated MW||44888 Da|
|Antigen Region||361-390 aa|
|Other Names||ETS domain-containing protein Elk-1, ELK1|
|Target/Specificity||This ELK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from human ELK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELK1 Antibody (S383) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).|
|Tissue Location||Lung and testis.|
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Provided below are standard protocols that you may find useful for product applications.
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein is a nuclear target for the ras-raf-MAPK signaling cascade.
Salinas, S., et al., J. Cell Biol. 165(6):767-773 (2004).
Yang, S.H., et al., Mol. Cell 12(1):63-74 (2003).
Bebien, M., et al., Oncogene 22(12):1836-1847 (2003).
Sharrocks, A.D., Biochem. Soc. Trans. 30(2):1-9 (2002).
Murai, K., et al., Mol. Cell. Biol. 22(20):7083-7092 (2002).
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