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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRB2 Antibody (Center)   

GRB2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GRB2 Antibody (Center) AP6283C
    Western blot analysis of GRB2 Antibody (Center) (Cat. #AP6283c) in A2058 cell line lysates (35ug/lane). GRB2 (arrow) was detected using the purified Pab.
  • WB - GRB2 Antibody (Center) AP6283C
    Western blot analysis of GRB2 (arrow) using GRB2 Antibody (Center) (Cat.#AP6283c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GRB2 gene (Lane 2) (Origene Technologies).
  • IHC-P - GRB2 Antibody (Center) AP6283C
    Formalin-fixed and paraffin-embedded human brain tissue reacted with GRB2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62993
Other Accession P62994, Q60631, Q6GPJ9, P87379
Reactivity Human
Predicted Xenopus, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25206 Da
Antigen Region 89-118 aa
Additional Information
Gene ID 2885
Other Names Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH
Target/Specificity This GRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the Central region of human GRB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRB2
Synonyms ASH
Function Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Cellular Location Nucleus. Cytoplasm. Endosome. Golgi apparatus
Research Areas
Citations (0)

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GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences.


Kondo,A., J. Biol. Chem. 283 (3), 1428-1436 (2008)
Morimatsu,M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007)
Martinez,N., Cell. Signal. 19 (11), 2277-2285 (2007)

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Cat# AP6283C
(40 western blots)
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