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INA (alpha internexin) Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q16352 |
| Other Accession | P23565, P46660, Q08DH7 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55391 Da |
| Antigen Region | 290-319 aa |
| Gene ID | 9118 |
|---|---|
| Other Names | Alpha-internexin, Alpha-Inx, 66 kDa neurofilament protein, NF-66, Neurofilament-66, Neurofilament 5, INA, NEF5 |
| Target/Specificity | This INA (alpha internexin) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from the Central region of human INA (alpha internexin). |
| Dilution | WB~~1:2000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INA (alpha internexin) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INA |
|---|---|
| Synonyms | NEF5 |
| Function | Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). |
| Tissue Location | Found predominantly in adult CNS. |
Provided below are standard protocols that you may find useful for product applications.
Background
INA is a class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
References
Armstrong,R.A.,Eur. J. Neurol. 13 (5), 528-532 (2006)
Suzuki,T., Eur. J. Neurosci. 21 (2), 339-350 (2005)
Cairns,N.J., Am. J. Pathol. 164 (6), 2153-2161 (2004)
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