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MEF2C Antibody (S59)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MEF2C Antibody (S59) AP6285c
    Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (S59) (RB11081). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEF2C gene (Lane 2) (Origene Technologies).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q06413
Other Accession Q03413, O89038, Q63943, Q14814, A4UTP7, Q8CFN5, Q2KIA0, Q03414, Q2MJT0, A2ICN5, Q60929, Q02078, Q9W6U8, A2VDZ3, Q98869, A0A096MJY4, Q9U325
Reactivity Human
Predicted Zebrafish, Bovine, Chicken, Mouse, Pig, Rat, Xenopus, C.Elegans
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 51221 Da
Antigen Region 37-66 aa
Additional Information
Gene ID 4208
Other Names Myocyte-specific enhancer factor 2C, MEF2C
Target/Specificity This MEF2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from human MEF2C.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEF2C Antibody (S59) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEF2C (HGNC:6996)
Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1.
Cellular Location Nucleus {ECO:0000250|UniProtKB:A0A096MJY4}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}
Tissue Location Expressed in brain and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. This protein controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It may also be involved in neurogenesis and in the development of cortical architecture.

References

Konig, S., et al., J. Biol. Chem. 279(27):28187-28196 (2004).
Maeda, T., et al., J. Biol. Chem. 277(50):48889-48898 (2002).
Maeda, T., et al., Biochem. Biophys. Res. Commun. 294(4):791-797 (2002).
Janson, C.G., et al., Brain Res. Mol. Brain Res. 97(1):70-82 (2001).
Krainc, D., et al., Genomics 29(3):809-811 (1995).

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$ 182.50
$ 70.00
Cat# AP6285c
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