|Application ||WB, E|
|Calculated MW||38590 Da|
|Antigen Region||220-252 aa|
|Other Names||Tax-responsive enhancer element B67; ATF4 protein|
|Target/Specificity||This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-252 amino acids from human ATF4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATF4 Antibody (S245) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). ATF4 belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain.
Gombart,A.F., J. Leukoc. Biol. 81 (6), 1535-1547 (2007)
Jousse,C., J. Biol. Chem. 282 (21), 15851-15861 (2007)
Kakiuchi,C., Neurosci. Lett. 417 (3), 316-321 (2007)
Marchand,A., J. Biol. Chem. 281 (28), 19124-19133 (2006)
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