|Application ||WB, IHC-P, FC, E|
|Calculated MW||36383 Da|
|Antigen Region||215-244 aa|
|Other Names||Mono [ADP-ribose] polymerase PARP16, ADP-ribosyltransferase diphtheria toxin-like 15, Poly [ADP-ribose] polymerase 16, PARP-16, PAR16|
|Target/Specificity||This PARP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human PARP16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PARP16 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono- ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP- ribosyltransferases (PubMed:22701565).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein has not been specifically defined.
Ame, J.C., et al. Bioessays 26(8):882-893(2004)
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