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Kallikrein 4 (KLK4) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Kallikrein 4 (KLK4) Antibody (Center) AP6323a
    Western blot analysis of anti-KLK4 Pab (Cat. #AP6323a) in mouse brain tissue lysate.KLK4(arrow) was detected using the purified Pab.
    detail
  • WB - Kallikrein 4 (KLK4) Antibody (Center) AP6323a
    Western blot analysis of KLK4 (arrow) using rabbit polyclonal KLK4 Antibody (S100) (Cat. #AP6323a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the KLK4 gene.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y5K2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27032 Da
Antigen Region 85-115 aa
Additional Information
Gene ID 9622
Other Names Kallikrein-4, 3421-, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Prostase, Serine protease 17, KLK4, EMSP1, PRSS17, PSTS
Target/Specificity This Kallikrein 4 (KLK4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-115 amino acids from the Central region of human Kallikrein 4 (KLK4).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKallikrein 4 (KLK4) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK4
Synonyms EMSP1, PRSS17, PSTS
Function Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in prostate.
Research Areas
Citations (0)
citation

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Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In some tissues KLK4 expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.

References

Hart, P.S., et al., J. Med. Genet. 41(7):545-549 (2004).
Xi, Z., et al., Cancer Res. 64(7):2365-2370 (2004).
Hural, J.A., et al., J. Immunol. 169(1):557-565 (2002).
Takayama, T.K., et al., Biochemistry 40(50):15341-15348 (2001).
Korkmaz, K.S., et al., DNA Cell Biol. 20(7):435-445 (2001).

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$ 182.50
$ 70.00
Cat# AP6323a
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