|Application ||WB, E|
|Calculated MW||27032 Da|
|Antigen Region||85-115 aa|
|Other Names||Kallikrein-4, 3421-, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Prostase, Serine protease 17, KLK4, EMSP1, PRSS17, PSTS|
|Target/Specificity||This Kallikrein 4 (KLK4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-115 amino acids from the Central region of human Kallikrein 4 (KLK4).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||Kallikrein 4 (KLK4) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||EMSP1, PRSS17, PSTS|
|Function||Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).|
|Tissue Location||Expressed in prostate.|
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Provided below are standard protocols that you may find useful for product applications.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In some tissues KLK4 expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.
Hart, P.S., et al., J. Med. Genet. 41(7):545-549 (2004).
Xi, Z., et al., Cancer Res. 64(7):2365-2370 (2004).
Hural, J.A., et al., J. Immunol. 169(1):557-565 (2002).
Takayama, T.K., et al., Biochemistry 40(50):15341-15348 (2001).
Korkmaz, K.S., et al., DNA Cell Biol. 20(7):435-445 (2001).
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