- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||32019 Da|
|Antigen Region||144-174 aa|
|Other Names||Kallikrein-5, 3421-, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, KLK5, SCTE|
|Target/Specificity||This Kallikrein 5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-174 amino acids from the Central region of human Kallikrein 5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Kallikrein 5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in desquamation.|
|Tissue Location||Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin|
Provided below are standard protocols that you may find useful for product applications.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK5 expression is up-regulated by estrogens and progestins. The protein is secreted and may be involved in desquamation in the epidermis.
Planque, C., et al., Biochem. Biophys. Res. Commun. 329(4):1260-1266 (2005). Michael, I.P., et al., J. Biol. Chem. 280(15):14628-14635 (2005). Ishida-Yamamoto, A., et al., J. Invest. Dermatol. 124(2):360-366 (2005). Brattsand, M., et al., J. Invest. Dermatol. 124(1):198-203 (2005). Caubet, C., et al., J. Invest. Dermatol. 122(5):1235-1244 (2004).
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