|Application ||WB, IHC-P, IF, E|
|Other Accession||P51794, Q61418|
|Calculated MW||84917 Da|
|Antigen Region||663-689 aa|
|Other Names||H(+)/Cl(-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4|
|Target/Specificity||This CLC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.|
|Cellular Location||Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein|
|Tissue Location||Abundant in skeletal muscle and also detectable in brain and heart|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.
Wang, T., et al., Gastroenterology 126(4):1157-1166 (2004).
Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31(3):657-666 (1999).
Dinulos, M.B., et al., Genomics 35(1):244-247 (1996).
Schnur, R.E., et al., Hum. Genet. 95(5):594-595 (1995).
van Slegtenhorst, M.A., et al., Hum. Mol. Genet. 3(4):547-552 (1994).
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