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Metabotropic Glutamate Receptor 1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Metabotropic Glutamate Receptor 1 Antibody (C-term) AP6341a
    Anti-GPRC1A Antibody (Y1111) at 1:1000 dilution + human brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 132 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - Metabotropic Glutamate Receptor 1 Antibody (C-term) AP6341a
    Metabotropic Glutamate Receptor 1 (GPRC1A) Antibody (C-term) (Cat. #AP6341a)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Metabotropic Glutamate Receptor 1 (GPRC1A) Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • WB - Metabotropic Glutamate Receptor 1 Antibody (C-term) AP6341a
    GPRC1A Antibody(Y1111) (Cat. #AP6341a) western blot analysis in CEM,NCI-H292,NCI-H460 cell line lysates (35ug/lane).This demonstrates the GPRC1A antibody detected the GPRC1A protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13255
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 132357 Da
Antigen Region 1096-1126 aa
Additional Information
Gene ID 2911
Other Names Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Target/Specificity This Metabotropic Glutamate Receptor 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1096-1126 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMetabotropic Glutamate Receptor 1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM1
Synonyms GPRC1A, MGLUR1
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain.
Research Areas
Citations (0)

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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 (also known as GPRC1A) and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM1 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. This protein may participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum


Hlavackova, V., et al., EMBO J. 24(3):499-509 (2005).
Kammermeier, P.J., et al., J. Pharmacol. Exp. Ther. 312(2):502-508 (2005).
Burgueno, J., et al., Exp. Cell Res. 300(1):23-34 (2004).
Mundell, S.J., et al., Mol. Pharmacol. 65(6):1507-1516 (2004).
Anneser, J.M., et al., J. Neuropathol. Exp. Neurol. 63(8):831-840 (2004).

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$ 295.00
$ 99.00
Cat# AP6341a
(40 western blots)
Availability: In Stock
Bulk Size
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