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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Metabotropic Glutamate Receptor 3 Antibody (C-term)   

Metabotropic Glutamate Receptor 3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Metabotropic Glutamate Receptor 3 Antibody (C-term) AP6343a
    GPRC1C Antibody (R841) (Cat. #AP6343a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GPRC1C antibody detected the GPRC1C protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14832
Other Accession Q1ZZH1
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 98879 Da
Antigen Region 828-857 aa
Additional Information
Gene ID 2913
Other Names Metabotropic glutamate receptor 3, mGluR3, GRM3, GPRC1C, MGLUR3
Target/Specificity This Metabotropic Glutamate Receptor 3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-857 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMetabotropic Glutamate Receptor 3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM3
Synonyms GPRC1C, MGLUR3
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala
Research Areas
Citations (0)

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Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 (also known as GPRC1C) while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM3 is mediated by a G-protein that inhibits adenylate cyclase activity.

References

Aronica, E., et al., Neuroscience 130(4):927-933 (2005).
Egan, M.F., et al., Proc. Natl. Acad. Sci. U.S.A. 101(34):12604-12609 (2004).
Yao, Y., et al., Biochem. Biophys. Res. Commun. 319(2):622-628 (2004).
Aronica, E., et al., Eur. J. Neurosci. 17(10):2106-2118 (2003).
Scherer, S.W., et al., Science 300(5620):767-772 (2003).

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$ 295.00
$ 99.00
Cat# AP6343a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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