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ZBTB7B Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZBTB7B Antibody (Center) AP6370c
    Western blot analysis of ZBTB7B Antibody (Center) Pab (Cat.#AP6370c) in mouse brain tissue lysates (35ug/lane). ZBTB7B (arrow) was detected using the purified Pab.
  • IHC-P - ZBTB7B Antibody (Center) AP6370c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ZBTB7B antibody (Center)(Cat.#AP6370c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O15156
Other Accession Q64321
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58027 Da
Antigen Region 181-210 aa
Additional Information
Gene ID 51043
Other Names Zinc finger and BTB domain-containing protein 7B, Krueppel-related zinc finger protein cKrox, hcKrox, T-helper-inducing POZ/Krueppel-like factor, Zinc finger and BTB domain-containing protein 15, Zinc finger protein 67 homolog, Zfp-67, Zinc finger protein 857B, Zinc finger protein Th-POK, ZBTB7B, ZBTB15, ZFP67, ZNF857B
Target/Specificity This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the Central region of human ZBTB7B.
Dilution WB~~1:1000
IHC-P~~1:50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZBTB7B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBTB7B
Synonyms ZBTB15, ZFP67, ZNF857B
Function Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

References

Galera,P., Proc. Natl. Acad. Sci. U.S.A. 91 (20), 9372-9376 (1994)
Widom,R.L., Gene 198 (1-2), 407-420 (1997)
Heegaard,A.M., J. Bone Miner. Res. 12 (12), 2050-2060 (1997)
Widom,R.L., Matrix Biol. 20 (7), 451-462 (2001)

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Cat# AP6370c
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(40 western blots)
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