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SNCA Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP6401b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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SNCA Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | P37840 |
| Other Accession | NP_009292 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 14460 Da |
SNCA Antibody (C-term) - Additional info | |
| Gene ID 6622 | |
| Other Names SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor | |
| Target/Specificity This alpha Synuclein antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82~112 amino acids from the C-terminal region of human Alpha-synuclein that recognizes both NACP112 and NCAP140. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SNCA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SNCA Antibody (C-term) - Protein Information | |
| Name SNCA | |
| Synonyms NACP, PARK1 | |
| Function May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | |
| Cellular Location Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons | |
| Tissue Location Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals | |
SNCA Antibody (C-term) - Related products
AP2955b: SNCA Antibody (C-term)
AP6401b: SNCA Antibody (C-term)
AP6404a: SNCA Antibody (C-term)
DC03597: Human SNCA cDNA Clone
LY10903a: SNCA Over-expression Lysate
BP2955b: SYUA Antibody (C-term) Blocking Peptide
BP6401b: Alpha-synuclein Antibody (C-term) Blocking Peptide
SNCA Antibody (C-term) - Application data
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Western blot analysis of Park1 (arrow) using rabbit polyclonal Park1 Antibody (C-term) (Cat. #AP6401b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Park1 gene.
SNCA Antibody (C-term) - Research Areas
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BACKGROUND
Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP112) lacks an alternate in-frame segment, compared to variant NACP140, resulting in a shorter protein (isoform NACP112) that has a distinct C-terminus, compared to isoform NACP140. This antibody recognizes both NACP112 and NCAP140.
REFERENCES
Kumru, H., et al., Ann. Neurol. 56(4):599-603 (2004). Pigullo, S., et al., Parkinsonism Relat. Disord. 10(6):357-362 (2004). Yao, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(29):10810-10814 (2004). West, A.B., et al., J. Biol. Chem. 279(28):28896-28902 (2004). Wang, F., et al., Genes Chromosomes Cancer 40(2):85-96 (2004).
