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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FXN Antibody (Center)   

FXN Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FXN Antibody (Center) AP6409C
    Western blot analysis of FXN Antibody (Center) (Cat.#AP6409c) in CEM cell line lysates (35ug/lane). FXN (arrow) was detected using the purified Pab.
  • IHC-P - FXN Antibody (Center) AP6409C
    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with FXN antibody (Center)(Cat.#AP6409c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - FXN Antibody (Center) AP6409C
    Confocal immunofluorescent analysis of FXN Antibody (Center)(Cat#AP6409c) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16595
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23135 Da
Antigen Region 72-102 aa
Additional Information
Gene ID 2395
Other Names Frataxin, mitochondrial, Friedreich ataxia protein, Fxn, Frataxin intermediate form, i-FXN, Frataxin(56-210), m56-FXN, Frataxin(78-210), d-FXN, m78-FXN, Frataxin mature form, Frataxin(81-210), m81-FXN, FXN, FRDA, X25
Target/Specificity This FXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-102 amino acids from the Central region of human FXN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFXN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FXN
Synonyms FRDA, X25
Function Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Cellular Location Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria
Tissue Location Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts.
Research Areas
Citations (0)

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FXN is a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia.

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Cat# AP6409C
(40 western blots)
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