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Synphilin-1 (SNCAIP) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Synphilin-1 (SNCAIP) Antibody (C-term) AP6411b
    All lanes : Anti-Synphilin-1 (C-term) at 1:1000 dilution Lane 1: human brain lysate Lane 2: U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 100 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - Synphilin-1 (SNCAIP) Antibody (C-term) AP6411b
    The anti-Synphilin-1 C-term Pab (Cat. #AP6411b) is used in Western blot to detect Synphilin-1 in mouse brain lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6H5
Other Accession NP_005451
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 100409 Da
Antigen Region 593-622 aa
Additional Information
Gene ID 9627
Other Names Synphilin-1, Sph1, Alpha-synuclein-interacting protein, SNCAIP
Target/Specificity This Synphilin-1 (SNCAIP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-622 amino acids from the C-terminal region of human Synphilin-1 (SNCAIP).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynphilin-1 (SNCAIP) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
Cellular Location Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA
Tissue Location Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta
Research Areas
Citations (0)

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Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease


Kruger,R. Cell Tissue Res. 318 (1), 195-199 (2004)
Lee,G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004)
Tanaka,M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004)
Nagano,Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003)
Marx,F.P., etal. Hum. Mol. Genet. 12 (11), 1223-1231 (2003)
Junn,E., et al. J. Biol. Chem. 277 (49), 47870-47877 (2002)
Chung,K.K., et al. Nat. Med. 7 (10), 1144-1150 (2001)
Kawamata,H., et al. J. Neurochem. 77 (3), 929-934 (2001)
Engelender,S., et al. Nat. Genet. 22 (1), 110-114 (1999)

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$ 295.00
$ 99.00
Cat# AP6411b
(40 western blots)
Availability: In Stock
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