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SUV4-20H2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SUV4-20H2 Antibody (Center) AP6511c
    Western blot analysis of SUV4-20H2 antibody (Center) (Cat.# AP6511c) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.
  • FC - SUV4-20H2 Antibody (Center) AP6511c
    SUV4-20H2 Antibody (Center) (Cat. #AP6511c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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  • CITATIONS: 1
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q86Y97
Other Accession P0C2N6, Q6Q783
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52113 Da
Antigen Region 4-20 aa
Additional Information
Gene ID 84787
Other Names Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2, SUV420H2, KMT5C
Target/Specificity This SUV4-20H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-214 amino acids from the Central region of human SUV4-20H2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSUV4-20H2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT5C (HGNC:28405)
Synonyms SUV420H2
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
Cellular Location Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Citations ( 0 )

Background

SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).

References

Souza,P.P., BMC Cell Biol. 10, 41 (2009)
Tryndyak,V.P., Cancer Biol. Ther. 5 (1), 65-70 (2006)

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$ 295.00
$ 99.00
Cat# AP6511c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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