|Application ||WB, FC, E|
|Calculated MW||28994 Da|
|Antigen Region||187-213 aa|
|Other Names||Emerin, EMD, EDMD, STA|
|Target/Specificity||This EMD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-213 amino acids from the C-terminal region of human EMD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||EMD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.|
|Cellular Location||Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus|
|Tissue Location||Skeletal muscle, heart, colon, testis, ovary and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.
Asioli,S., Histopathology 54 (5), 571-579 (2009)
Tilgner,K., J. Cell. Sci. 122 (PT 3), 401-413 (2009)
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