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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EMD Antibody (C-term)   

EMD Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EMD Antibody (C-term) AP6525b
    Western blot analysis of EMD antibody (C-term) (Cat.# AP6525b) in MCF-7 cell line lysates (35ug/lane). EMD (arrow) was detected using the purified Pab.
  • FC - EMD Antibody (C-term) AP6525b
    Flow cytometric analysis of MDA-231 cells using EMD Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50402
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28994 Da
Antigen Region 187-213 aa
Additional Information
Gene ID 2010
Other Names Emerin, EMD, EDMD, STA
Target/Specificity This EMD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-213 amino acids from the C-terminal region of human EMD.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEMD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EMD
Synonyms EDMD, STA
Function Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Cellular Location Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus
Tissue Location Skeletal muscle, heart, colon, testis, ovary and pancreas
Research Areas
Citations (0)

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Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.


Asioli,S., Histopathology 54 (5), 571-579 (2009)
Tilgner,K., J. Cell. Sci. 122 (PT 3), 401-413 (2009)

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$ 295.00
$ 99.00
Cat# AP6525b
(40 western blots)
Availability: In Stock
Bulk Size
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