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ACDC Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6531a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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ACDC Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q15848 |
| Other Accession | Q3Y5Z3 |
| Reactivity | Human |
| Predicted | Bovine |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 26414 Da |
ACDC Antibody (N-term) - Additional info | |
| Gene ID 9370 | |
| Other Names ADIPOQ; ACDC; ACRP30; APM1; GBP28; Adiponectin; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; Gelatin-binding protein | |
| Target/Specificity This ACDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51~81 amino acids from the N-terminal region of human ACDC. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACDC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACDC Antibody (N-term) - Protein Information | |
| Name ADIPOQ | |
| Synonyms ACDC, ACRP30, APM1, GBP28 | |
| Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW | |
| Cellular Location Secreted. | |
| Tissue Location Synthesized exclusively by adipocytes and secreted into plasma | |
ACDC Antibody (N-term) - Related products
AP6531a: ACDC Antibody (N-term)
AP6531b: ACDC Antibody (C-term)
RI10144: ADIPOQ predesign siRNA
DC09081: Human ADIPOQ cDNA Clone
LY12086a: ADIPOQ Over-expression Lysate
BP6531a: ACDC Antibody (N-term) Blocking Peptide
ACDC Antibody (N-term) - Application data
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Western blot analysis of ACDC antibody (N-term) (Cat.# AP6531a) in NCI-H460 cell line lysates (35ug/lane). ACDC (arrow) was detected using the purified Pab.
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(LEFT)Formalin-fixed and paraffin-embedded human lung carcinoma with ACDC Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (RIGHT)Flow cytometric analysis of NCI-H292 cells using ACDC Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ACDC Antibody (N-term) - Research Areas
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BACKGROUND
ACDC is expressed in adipose tissue exclusively. It is a protein with similarity to collagens X and VIII and complement factor C1q. The protein circulates in the plasma and is involved with metabolic and hormonal processes.
REFERENCES
Wang,Y., J. Biol. Chem. 277 (22), 19521-19529 (2002) Schaffler,A., Biochim. Biophys. Acta 1399 (2-3), 187-197 (1998)
