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RBL2/p130 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6543c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
RBL2/p130 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q08999 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 128367 Da |
RBL2/p130 Antibody (Center) - Additional info | |
| Gene ID 5934 | |
| Other Names RBL2; RB2; Retinoblastoma-like protein 2; 130 kDa retinoblastoma-associated protein; Retinoblastoma-related protein 2; pRb2 | |
| Target/Specificity This RBL2/p130 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593~622 amino acids from the Center region of human RBL2. | |
| Dilution WB~~1:50~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RBL2/p130 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RBL2/p130 Antibody (Center) - Protein Information | |
| Name RBL2 | |
| Synonyms RB2 | |
| Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor | |
| Cellular Location Nucleus. | |
RBL2/p130 Antibody (Center) - Related products
AP12224a: RBL2 Antibody (N-term)
AP6543a: RBL2/p130 Antibody (N-term)
AP6543c: RBL2/p130 Antibody (Center)
BP6543a: RBL2/p130 Antibody (N-term) Blocking Peptide
BP6543c: RBL2/p130 Antibody (Center) Blocking Peptide
AT3590a: RBL2 Antibody (monoclonal) (M03)
AT3591a: RBL2 Antibody (monoclonal) (M05)
RBL2/p130 Antibody (Center) - Application data
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Western blot analysis of RBL2/p130 antibody (Center) (Cat.# AP6543c) in mouse kidney tissue lysates (35ug/lane). RBL2/p130 (arrow) was detected using the purified Pab.
RBL2/p130 Antibody (Center) - Research Areas
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BACKGROUND
RBL2 is a key regulator of entry into cell division. The protein is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
REFERENCES
Priya,K., Cancer Biol. Ther. 8 (8), 714-717 (2009) Fields,A.L., J. Cell. Physiol. 217 (1), 77-85 (2008) Masciullo,V., Clin. Cancer Res. 14 (15), 4775-4779 (2008)
