|Application ||WB, IHC-P, E|
|Calculated MW||40108 Da|
|Antigen Region||122-148 aa|
|Other Names||Hereditary hemochromatosis protein, HLA-H, HFE, HLAH|
|Target/Specificity||This HFE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-148 amino acids from the Central region of human HFE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HFE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in all tissues tested except brain.|
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Provided below are standard protocols that you may find useful for product applications.
HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in its gene.
Valenti,L., Clin J Am Soc Nephrol 4 (8), 1331-1337 (2009)
Won,J.E., Intervirology 52 (5), 239-246 (2009)
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