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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HFE Antibody (Center)   

HFE Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HFE Antibody (Center) AP6544c
    Western blot analysis of HFE antibody (Center) (Cat.# AP6544c) in Jurkat cell line lysates (35ug/lane). HFE (arrow) was detected using the purified Pab.
  • IHC-P - HFE Antibody (Center) AP6544c
    HFE Antibody (Center) (Cat.# AP6544c) IHC analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HFE Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q30201
Other Accession O35799
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40108 Da
Antigen Region 122-148 aa
Additional Information
Gene ID 3077
Other Names Hereditary hemochromatosis protein, HLA-H, HFE, HLAH
Target/Specificity This HFE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-148 amino acids from the Central region of human HFE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHFE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HFE
Synonyms HLAH
Function Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in all tissues tested except brain.
Research Areas
Citations (0)

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HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in its gene.


Valenti,L., Clin J Am Soc Nephrol 4 (8), 1331-1337 (2009)
Won,J.E., Intervirology 52 (5), 239-246 (2009)

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$ 295.00
$ 99.00
Cat# AP6544c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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