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CPZ Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CPZ Antibody (N-term) AP6546a
    Western blot analysis of CPZ Antibody (N-term) (Cat.# AP6546a) in K562 cell line lysates (35ug/lane). CPZ (arrow) was detected using the purified Pab.
  • IHC-P - CPZ Antibody (N-term) AP6546a
    Formalin-fixed and paraffin-embedded human placenta with CPZ Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q66K79
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 73655 Da
Antigen Region 143-172 aa
Additional Information
Gene ID 8532
Other Names Carboxypeptidase Z, CPZ, 3417-, CPZ
Target/Specificity This CPZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the N-terminal region of human CPZ.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPZ Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPZ
Function Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.
Research Areas
Citations (0)

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CPZ is a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases.


Fan,X., J. Histochem. Cytochem. 50 (11), 1509-1516 (2002)
Reznik,S.E., Cell. Mol. Life Sci. 58 (12-13), 1790-1804 (2001)

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Cat# AP6546a
(40 western blots)
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