|Application ||WB, IHC-P, E|
|Calculated MW||103276 Da|
|Antigen Region||709-737 aa|
|Other Names||Puromycin-sensitive aminopeptidase, PSA, Cytosol alanyl aminopeptidase, AAP-S, NPEPPS, PSA|
|Target/Specificity||This PSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 709-737 amino acids from the C-terminal region of human PSA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.|
|Cellular Location||Cytoplasm, cytosol. Nucleus|
|Tissue Location||Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
PSA is the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.
Thompson,M.W., Peptides 24 (9), 1359-1365 (2003)
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