|Application ||WB, FC, E|
|Other Accession||O08600, P38447|
|Calculated MW||32620 Da|
|Antigen Region||188-217 aa|
|Other Names||Endonuclease G, mitochondrial, Endo G, 3130-, ENDOG|
|Target/Specificity||This ENDOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the C-terminal region of human ENDOG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENDOG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ENDOG is a nuclear encoded endonuclease that is localized in the mitochondrion. The protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
Noda,T., Apoptosis 14 (3), 287-297 (2009)
Wu,S.L., J. Biomed. Sci. 16, 6 (2009)
Ahn,C.H., APMIS 116 (6), 534-537 (2008)
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