|Application ||WB, IHC-P, FC, E|
|Calculated MW||44565 Da|
|Antigen Region||40-69 aa|
|Other Names||Serpin B3, Protein T4-A, Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA, SCCA1|
|Target/Specificity||This SPB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SPB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPB3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).|
|Cellular Location||Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level|
|Tissue Location||Squamous cells. Expressed in some hepatocellular carcinoma (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
SPB3 may act as a protease inhibitor to modulate the host immune response against tumor cells.
Turato,C., Dig Liver Dis 41 (3), 212-216 (2009)
Ahmed,S.T., Biochem. Biophys. Res. Commun. 378 (4), 821-825 (2009)
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