|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||108529 Da|
|Antigen Region||831-858 aa|
|Other Names||Collagen alpha-1(VI) chain, COL6A1|
|Target/Specificity||This COL6A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 831-858 amino acids from the C-terminal region of human COL6A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL6A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Collagen VI acts as a cell-binding protein.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The protein COL6A1 is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
Martoni,E., Hum. Mutat. 30 (5), E662-E672 (2009)
Kim,T.H., J. Rheumatol. 35 (9), 1849-1852 (2008)
Fujita,A., Genet. Mol. Res. 7 (2), 371-378 (2008)
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