|Application ||WB, IHC-P, FC, E|
|Calculated MW||43000 Da|
|Antigen Region||193-222 aa|
|Other Names||Protein Wnt-10b, Protein Wnt-12, WNT10B, WNT12|
|Target/Specificity||This WNT10B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-222 amino acids from the Central region of human WNT10B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WNT10B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT10B is a member of the WNT family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level.
Zmuda,J.M., J. Bone Miner. Res. 24 (3), 437-447 (2009)
Pederson,L., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20764-20769 (2008)
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