- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||25809 Da|
|Antigen Region||176-203 aa|
|Other Names||CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28, CD81, CD81, TAPA1, TSPAN28|
|Target/Specificity||This CD81 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-203 amino acids from the C-terminal region of human CD81.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD81 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines|
Provided below are standard protocols that you may find useful for product applications.
CD81 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction.
Weng,J., J. Virol. 83 (15), 7467-7474 (2009)
Rocha-Perugini,V., BMC Microbiol. 9, 111 (2009)
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