|Application ||WB, IHC-P, FC, E|
|Calculated MW||104399 Da|
|Antigen Region||247-276 aa|
|Other Names||RNA polymerase II subunit A C-terminal domain phosphatase, TFIIF-associating CTD phosphatase, CTDP1, FCP1|
|Target/Specificity||This CTDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the N-terminal region of human CTDP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTDP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
CTDP1 is a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex.
Hirose,Y., Biochem. Biophys. Res. Commun. 369 (2), 449-455 (2008)
Abbott,K.L., Biochemistry 44 (8), 2716-2731 (2005)
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