|Application ||WB, FC, E|
|Other Accession||Q6MG77, O70348, Q5E9Y5|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||44929 Da|
|Antigen Region||73-99 aa|
|Other Names||Decapping and exoribonuclease protein, DXO, 3113-, 361-, Dom-3 homolog Z, DXO, DOM3L, DOM3Z, NG6|
|Target/Specificity||This DOM3Z antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-99 amino acids from the N-terminal region of human DOM3Z.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DOM3Z Antibody (N-term Y88) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DOM3L, DOM3Z, NG6|
|Function||Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The function of DOM3Z is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that its gene may be a housekeeping gene.
Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)
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