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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAB13 Antibody (Center)   

RAB13 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RAB13 Antibody (Center) AP6667c
    Western blot analysis of RAB13 antibody (Center) (Cat. #AP6667c) in mouse bladder tissue lysates (35ug/lane). RAB13 (arrow) was detected using the purified Pab.
  • IHC-P - RAB13 Antibody (Center) AP6667c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with RAB13 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - RAB13 Antibody (Center) AP6667c
    Flow cytometric analysis of 293 cells using RAB13 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51153
Other Accession Q58DS5
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22774 Da
Antigen Region 109-137 aa
Additional Information
Gene ID 5872
Other Names Ras-related protein Rab-13, Cell growth-inhibiting gene 4 protein, RAB13
Target/Specificity This RAB13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the Central region of human RAB13.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB13
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin- induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, secretory vesicle membrane. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells
Tissue Location Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells
Research Areas
Citations (0)

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RAB13 can participate in polarized transport, in the assembly and/or the activity of tight junctions.


Nokes,R.L., J. Cell Biol. 182 (5), 845-853 (2008)
Kanda,I., Oncogene 27 (12), 1687-1695 (2008)

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Cat# AP6667c
(40 western blots)
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