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TALDO1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TALDO1 Antibody (Center) AP6679c
    Western blot analysis of TALDO1 antibody (Center) (Cat. #AP6679c) in A375 cell line lysates (35ug/lane). TALDO1 (arrow) was detected using the purified Pab.
    detail
  • WB - TALDO1 Antibody (Center) AP6679c
    Western blot analysis of TALDO1 (arrow) using rabbit polyclonal TALDO1 Antibody (Center) (Cat. #AP6679c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TALDO1 gene.
    detail
  • IHC-P - TALDO1 Antibody (Center) AP6679c
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with TALDO1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - TALDO1 Antibody (Center) AP6679c
    Flow cytometric analysis of K562 cells using TALDO1 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, IHC-P, E
Primary Accession P37837
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 37540 Da
Antigen Region 186-215 aa
Additional Information
Gene ID 6888
Other Names Transaldolase, TALDO1, TAL, TALDO, TALDOR
Target/Specificity This TALDO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the Central region of human TALDO1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTALDO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TALDO1 (HGNC:11559)
Synonyms TAL, TALDO, TALDOR
Function Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:8955144, PubMed:18687684). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).
Cellular Location [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q93092}. Cytoplasm {ECO:0000250|UniProtKB:Q93092}. Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1 {ECO:0000250|UniProtKB:Q93092}
Research Areas
Citations (0)
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Background

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals.

References

Schneider,S., J. Biol. Chem. 283 (44), 30064-30072 (2008)
Qian,Y., Biochem. J. 415 (1), 123-134 (2008)
Wamelink,M.M., J. Inherit. Metab. Dis. 30 (5), 735-742 (2007)

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$ 365.00
$ 140.00
Cat# AP6679c
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