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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAN Antibody (Center)   

RAN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RAN Antibody (Center) AP6693b
    RAN Antibody (Center) (Cat. #AP6693b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the RAN antibody detected the RAN protein (arrow).
  • IHC-P - RAN Antibody (Center) AP6693b
    RAN antibody (Center) (Cat. #AP6693b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RAN antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - RAN Antibody (Center) AP6693b
    RAN Antibody (Center) (Cat. #AP6693b) flow cytometric analysis of NIH-3T3 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62826
Other Accession P52301, P62828, P62827, Q4R4M9, Q9VZ23, P79735, P42558, Q3T054, NP_006316.1
Reactivity Human, Mouse
Predicted Bovine, Chicken, Zebrafish, Drosophila, Monkey, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 24423 Da
Antigen Region 112-140 aa
Additional Information
Gene ID 5901
Other Names GTP-binding nuclear protein Ran, Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, RAN, ARA24
Target/Specificity This RAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the Central region of human RAN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAN
Synonyms ARA24
Function GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
Cellular Location Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity) Becomes dispersed throughout the cytoplasm during mitosis Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.


Kim, J.S., et al. Mol. Carcinog. 49(10):913-921(2010)
Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)
Boni, V., et al. Pharmacogenomics J. (2010) In press :
Ly, T.K., et al. J. Biol. Chem. 285(8):5815-5826(2010)
Mishra, R.K., et al. Nat. Cell Biol. 12(2):164-169(2010)

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$ 295.00
$ 99.00
Cat# AP6693b
(40 western blots)
Availability: In Stock
Bulk Size
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