|Application ||WB, FC, E|
|Other Accession||P09077, P10628, P09016, P17278, O57374, P02832, P10629, P09630, P15862, P09020, P32043, Q00444, P09074, P04476, Q91771, P14839, Q9YGT4, P15861, P09019, P09079, P09067, P14838, P09013, P09014, P09071, P09634, P02830, P31268, Q90VZ9, P09092, P31267, Q5YLH5|
|Predicted||Drosophila, Zebrafish, Chicken, Sheep, Bovine, Rat, Xenopus|
|Calculated MW||29345 Da|
|Antigen Region||196-223 aa|
|Other Names||Homeobox protein Hox-A5, Homeobox protein Hox-1C, HOXA5, HOX1C|
|Target/Specificity||This HOXA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-223 amino acids from the C-terminal region of human HOXA5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOXA5 Antibody (C-term E211) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA5 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
Chen,Y., Blood 111 (3), 1217-1226 (2008)
Chen,H., Cancer Res. 67 (17), 8007-8013 (2007)
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