|Application ||WB, IHC-P, FC, E|
|Other Accession||Q6IFU7, Q6IFX2, Q6IFU8, Q9QWL7, Q04695, A1L595, Q6IFV1, Q61781|
|Calculated MW||51561 Da|
|Antigen Region||276-303 aa|
|Other Names||Keratin, type I cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14, KRT14|
|Target/Specificity||This KRT14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-303 amino acids from the Central region of human KRT14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KRT14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.|
|Cellular Location||Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern|
|Tissue Location||Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.|
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Provided below are standard protocols that you may find useful for product applications.
KRT14 is a member of the keratin family, the most diverse group of intermediate filaments. This protein, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells.
Barcelos,A.C., J. Cutan. Pathol. 36 (6), 647-654 (2009) Romano,R.A., PLoS ONE 4 (5), E5623 (2009)
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