- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||11284 Da|
|Antigen Region||74-103 aa|
|Other Names||Dermcidin, 34--, Preproteolysin, Survival-promoting peptide, DCD-1, DCD, AIDD, DSEP|
|Target/Specificity||This DCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-103 amino acids from the C-terminal region of human DCD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.|
|Tissue Location||Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml|
Provided below are standard protocols that you may find useful for product applications.
DCD is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
Todorov,P.T., J. Biol. Chem. 272 (19), 12279-12288 (1997)
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