|Application ||WB, E|
|Other Accession||Q9N0J6, Q2KJJ9|
|Calculated MW||36743 Da|
|Antigen Region||250-281 aa|
|Other Names||Fructose-1, 6-bisphosphatase isozyme 2, FBPase 2, D-fructose-1, 6-bisphosphate 1-phosphohydrolase 2, Muscle FBPase, FBP2|
|Target/Specificity||This FBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-281 amino acids from the C-terminal region of human FBP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.|
|Cellular Location||Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration.|
|Tissue Location||Expressed in skeletal muscle (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
FBP2 is a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.
Gizak,A., Proteins 72 (1), 209-216 (2008)
Rakus,D., FEBS Lett. 579 (25), 5577-5581 (2005)
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