|Application ||WB, IHC-P, FC, E|
|Other Accession||P45878, Q32PA9|
|Calculated MW||15649 Da|
|Antigen Region||11-41 aa|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP2, PPIase FKBP2, 13 kDa FK506-binding protein, 13 kDa FKBP, FKBP-13, FK506-binding protein 2, FKBP-2, Immunophilin FKBP13, Rotamase, FKBP2, FKBP13|
|Target/Specificity||This FKBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human FKBP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FKBP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein|
|Tissue Location||T-cells and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
FKBP2 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds.
Padilla,P.I., Proc. Natl. Acad. Sci. U.S.A. 100 (5), 2322-2327 (2003)
Bush,K.T., Biochem. J. 303 (PT 3), 705-708 (1994)
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