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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BGN Antibody (Center)   

BGN Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BGN Antibody (Center) AP6740c
    Western blot analysis of BGN (arrow) using rabbit polyclonal BGN Antibody (Center) (Cat. #AP6740c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the BGN gene.
  • WB - BGN Antibody (Center) AP6740c
    Western blot analysis of BGN Antibody (Center) (Cat. #AP6740c) in Sk-Br-3 cell line lysates (35ug/lane). BGN (arrow) was detected using the purified Pab.
  • IHC-P - BGN Antibody (Center) AP6740c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with BGN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - BGN Antibody (Center) AP6740c
    BGN Antibody (Center) (Cat. #AP6740c) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21810
Other Accession P47853, P28653, P21809, O46403, O46390
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41654 Da
Antigen Region 148-176 aa
Additional Information
Gene ID 633
Other Names Biglycan, Bone/cartilage proteoglycan I, PG-S1, BGN, SLRR1A
Target/Specificity This BGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the Central region of human BGN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBGN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BGN
Synonyms SLRR1A
Function May be involved in collagen fiber assembly.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Found in several connective tissues, especially in articular cartilages
Research Areas
Citations (0)

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BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival.


Sardo,M.A., Clin. Chim. Acta 406 (1-2), 89-93 (2009)
Hwang,J.Y., Am. J. Pathol. 173 (6), 1919-1928 (2008)
Traupe,H., Genomics 13 (2), 481-483 (1992)

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Cat# AP6740c
(40 western blots)
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