|Application ||WB, FC, E|
|Calculated MW||38206 Da|
|Antigen Region||57-85 aa|
|Other Names||3-keto-steroid reductase, 17-beta-hydroxysteroid dehydrogenase 7, 17-beta-HSD 7, Estradiol 17-beta-dehydrogenase 7, HSD17B7|
|Target/Specificity||This HSD17B7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human HSD17B7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HSD17B7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the reduction of the keto group on the C-3 of sterols.|
|Cellular Location||Cell membrane; Single-pass membrane protein.|
|Tissue Location||Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
HSD17B7 oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.
Plourde,M., et.al.,J. Steroid Biochem. Mol. Biol. 116 (3-5), 134-153 (2009)
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