|Application ||WB, IHC-P, FC, E|
|Calculated MW||55885 Da|
|Antigen Region||207-234 aa|
|Other Names||Interleukin-17 receptor B, IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, IL-17Rh1, IL17Rh1, Interleukin-17B receptor, IL-17B receptor, IL17RB, CRL4, EVI27, IL17BR|
|Target/Specificity||This IL17_ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-234 amino acids from the Central region of human IL17_.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL17RB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CRL4, EVI27, IL17BR|
|Function||Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines|
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Provided below are standard protocols that you may find useful for product applications.
IL17RB is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E.
Goetz,M.P., et.al., Clin. Cancer Res. 14 (18), 5864-5868 (2008)
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