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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KYNU Antibody (C-term)   

KYNU Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KYNU Antibody (C-term) AP6768b
    Western blot analysis of KYNU Antibody (C-term) (Cat. #AP6768b) in NCI-H460 cell line lysates (35ug/lane). KYNU (arrow) was detected using the purified Pab.
  • IHC-P - KYNU Antibody (C-term) AP6768b
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with KYNU Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - KYNU Antibody (C-term) AP6768b
    KYNU Antibody (C-term) (Cat. #AP6768b) flow cytometry analysis of NCI-H292 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16719
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52352 Da
Antigen Region 359-386 aa
Additional Information
Gene ID 8942
Other Names Kynureninase {ECO:0000255|HAMAP-Rule:MF_03017}, 3713 {ECO:0000255|HAMAP-Rule:MF_03017}, L-kynurenine hydrolase {ECO:0000255|HAMAP-Rule:MF_03017}, KYNU {ECO:0000255|HAMAP-Rule:MF_03017}
Target/Specificity This KYNU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-386 amino acids from the C-terminal region of human KYNU.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKYNU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KYNU {ECO:0000255|HAMAP-Rule:MF_03017}
Function Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}
Tissue Location Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas) Highest levels found in placenta, liver and lung. Expressed in all brain regions.
Research Areas
Citations (0)

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KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. KYNU is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway.


Christensen,M.,, J. Inherit. Metab. Dis. 30 (2), 248-255 (2007)

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$ 295.00
$ 99.00
Cat# AP6768b
(40 western blots)
Availability: In Stock
Bulk Size
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